Article
Molecular studies in three patients with isodicentric Y chromosome.
Human genetics - 1 Dec 1996
Stuppia L, Calabrese G, Franchi P G, Mingarelli R, Morizio E, Sabatino G, Palka G
Abstract excerpt
Three patients carrying an isodicentric (idic) Y chromosome associated with a mosaic 45,X cell line were studied using molecular techniques. Genotype-phenotype correlations suggested an effect of the 45,X cell line on sexual differentiation. A relationship was established between instability of the idic(Y) chromosome and localization of the breakpoint on Yq, and between azoospermia and deletion of interval 6 on Yq.
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