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Article

Expression studies of delta-globin gene alleles associated with reduced hemoglobin A2 levels in Greek Cypriots.

The Journal of biological chemistry - 25 Oct 1996

Trifillis P, Adachi K, Yamaguchi T, Schwartz E, Surrey S

Abstract excerpt

We previously identified five delta-globin gene alleles associated with reduced hemoglobin (Hb) A2 (Trifillis, P., Ioannou, P., Schwartz, E., and Surrey, S. (1991) Blood 78, 3298-3305). We have now evaluated functional consequences of the changes after expression in COS-1 cells to monitor effects on RNA splicing. In addition, variant Hb A2 tetramers were expressed in yeast to assess effects of amino acid changes...

Topics

Alleles
Animals
Biopolymers
COS Cells
Cyprus
Genetics, Population
Globins
Hemoglobin A2
Humans
Mutagenesis, Site-Directed
Mutation
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splicing

Source

Identifiers

PMID: 8900178
DOI: 10.1074/jbc.271.43.26931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8900178-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Expression studies of delta-globin gene alleles associated with reduced hemoglobin A2 levels in Greek Cypriots.PMID 8900178Read ↗

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