Article
Identification of four novel delta-globin gene mutations in Greek Cypriots using polymerase chain reaction and automated fluorescence-based DNA sequence analysis.
Blood - 15 Dec 1991
Trifillis P, Ioannou P, Schwartz E, Surrey S
Abstract excerpt
The molecular basis of most beta-thalassemia syndromes has been defined, while the spectrum of mutations causing delta-thalassemia is not well characterized. In an attempt to identify such mutations, the region encompassing the delta-globin gene from three Greek Cypriot families suspected of havi...
Topics
- Autoanalysis
- Base Sequence
- Cyprus
- DNA
- Fluorescent Dyes
- Globins
- Greece
- Hemoglobin A2
- Heterozygote
- Homozygote
- Humans
- Molecular Sequence Data
- Mutation
- Pedigree
- Polymerase Chain Reaction
- Thalassemia