Article
On planning of samples for linkage analysis: two ways of a sample size reduction.
Genetic epidemiology - 1 Jan 1996
Ginsburg E K, Axenovich T I
Abstract excerpt
The sample size required for a given type I and type II errors of linkage decision is determined by using the earlier proposed method of the linkage test power estimation [Ginsburg et al., 1996]. Dependence of the sample size on the heterozygotic genotype penetrance is investigated. Two approaches to sample size reduction are considered: the choice of marker gene and the special extension of analyzed pedigree...
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