Signal transduction as target of gene therapy.

doi:10.1007/978-3-642-80035-1_5

Article

Signal transduction as target of gene therapy.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer - 1 Jan 1996

Moelling K, Strack B, Radziwill G

Abstract excerpt

Cancer development involves multistep events. Therapeutic approaches can be targeted against any of these events individually or in combination. Pancreatic cancer can involve activation of Ki-Ras, overexpression of Myc or ErbB-2, and mutational inactivation of functional p53. Three approaches with nucleic acid-based therapies have been taken. A ribozyme specific for Ki-ras mRNA carrying the activating mutation in...

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