Article
Presymptomatic molecular diagnosis of autosomal dominant polycystic kidney disease using PKD1- and PKD2-linked markers in Cypriot families.
Clinical genetics - 1 Jul 1996
Deltas C C, Christodoulou K, Tjakouri C, Pierides A
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD), is a heterogeneous disorder, primarily characterized by the formation of cysts in the kidneys, and the late development in life of progressive chronic kidney failure. Three genes are implicated in causing ADPKD. One on chromosome 16, PKD1, acc...
Topics
- Adult
- Age Factors
- Aged
- Base Sequence
- Chromosomes, Human, Pair 16
- Cyprus
- Dinucleotide Repeats
- Female
- Genetic Linkage
- Genetic Markers
- Haplotypes
- Humans
- Infant
- Male
- Membrane Proteins
- Middle Aged
- Molecular Sequence Data
- Mutation