Article
Characterization of dentatorubral-pallidoluysian atrophy proteins using two-dimensional electrophoretic analysis.
Brain research - 2 Sept 1996
Yazawa I, Nukina N, Kanazawa I
Abstract excerpt
The genetic defect dentatorubral-pallidoluysian atrophy (DRPLA) is known to be an expansion of a CAG trinucleotide repeat. The mutant gene has been demonstrated to be translated into protein, and this protein contains an expanded polyglutamine region. In the present study, we have demonstrated using two-dimensional gel electrophoresis and immunoblotting that the DRPLA gene products consist of a number of...
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