Article
[The mechanisms of aging and perspective for elimination of deleterious effects].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics - 1 Jul 1996
Fujiwara Y
Abstract excerpt
Genetic programs and age-dependent changes in DNA and protein are involved in aging. The genetic program governs body weight, longevity, aging rate, sex-maturating period and metabolic rate in mammals, and such a number of life history variables are highly correlated with body size. Monogenic age-1 and daf-2 C. elegans mutants extend life span twice. However, human monogenic progeroids shorten lifespan. The...
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