Article
Level of myelopoiesis in the bone marrow is influenced by intestinal flora.
Cellular immunology - 10 Oct 1996
Tada T, Yamamura S, Kuwano Y, Abo T
Abstract excerpt
Mice were orally given kanamycin (50 mg/day/ mouse) for 1 or 2 weeks. Almost all bacteria in the intestine were eliminated within a week. In parallel with this elimination, the level of granulocytes in the bone marrow decreased from 41 to 31%. Since the total number of bone marrow cells decreased as well (up to one-third), the decrease in the level of granulocyte generation in the bone marrow was substantial....
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