Genetic variation and evolutionary stability of the FMR1 CGG repeat in six closed human populations.

doi:10.1002/(SICI)1096-8628(19960712)64:1<220::AID-AJMG40>3.0.CO;2-M

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Article

Genetic variation and evolutionary stability of the FMR1 CGG repeat in six closed human populations.

American journal of medical genetics - 12 Jul 1996

Eichler E E, Nelson D L

Abstract excerpt

In an attempt to understand the allelic diversity and mutability of the human FMR1 CGG repeat, we have analyzed the AGG substructure of this locus within six genetically-closed populations (Mbuti pygmy, Baka pygmy, R. surui, Karitiana, Mayan, and Hutterite). Most alleles (61/92 or 66%) possessed two AGG interspersions occurring with a periodicity of one AGG every nine or ten CGG repeats, indicating that this...

Topics

Biological Evolution
Female
Fragile X Mental Retardation Protein
Fragile X Syndrome
Genetic Variation
Heterozygote
Humans
Male
Nerve Tissue Proteins
Pedigree
RNA-Binding Proteins
Trinucleotide Repeats

Source

Open in PubMed

Identifiers

PMID: 8826480
DOI: 10.1002/(SICI)1096-8628(19960712)64:1<220::AID-AJMG40>3.0.CO;2-M

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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