Article
In vivo oxidation of [13C]galactose in patients with galactose-1-phosphate uridyltransferase deficiency.
Biochemical and molecular medicine - 1 Dec 1995
Berry G T, Nissim I, Mazur A T, Elsas L J, Singh R H, Klein P D, Gibson J B, Lin Z, Segal S
Abstract excerpt
We developed an intravenous and oral [13C]galactose breath test for the in vivo study of galactose metabolism. Following an intravenous bolus of 7 mg/kg of [1-13C]galactose in the fasting state, normal children and adults eliminated 3-6% and 21-47% of the bolus as 13CO2 in expired air collected over 1 and 5 h, respectively. Comparable fractional elimination was seen when the dose was given orally. Patients with...
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