Article
Mutational analysis of the beta-subunit of yeast geranylgeranyl transferase I.
Molecular & general genetics : MGG - 27 Aug 1996
Ohya Y, Caplin B E, Qadota H, Tibbetts M F, Anraku Y, Pringle J R, Marshall M S
Abstract excerpt
The gene CAL1 (also known as CDC43) of Saccharomyces cerevisiae encodes the beta subunit of geranylgeranyl transferase I (GGTase I), which modifies several small GTPases. Biochemical analyses of the mutant enzymes encoded by cal1-1, and cdc43-2 to cdc43-7, expressed in bacteria, have shown that all of the mutant enzymes possess reduced activity, and that none shows temperature-sensitive enzymatic activities....
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