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Article

The mechanism of velocity modulated allosteric regulation in D-3-phosphoglycerate dehydrogenase. Site-directed mutagenesis of effector binding site residues.

The Journal of biological chemistry - 20 Sept 1996

Al-Rabiee R, Zhang Y, Grant G A

Abstract excerpt

D-3-Phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli catalyzes the first committed step in serine biosynthesis and is allosterically regulated by L-serine, the end product of the pathway. Each subunit of the homotetramer is made up of three distinct domains with one of the inter...

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Source

Identifiers

PMID: 8798520
DOI: 10.1074/jbc.271.38.23235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8798520-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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