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Metalloproteinases and their roles in human cancer

6 Jun 2019

Abstract excerpt

It is now widely appreciated that members of the matrix metalloproteinase (MMP) family of enzymes play a key role in cancer development and progression along with many of the hallmarks associated with them. The activity of these enzymes has been directly implicated in extracellular matrix remodeling, the processing of growth factors and receptors, the modulation of cell migration, proliferation, and invasion, the...

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PMID: 31168956
DOI: 10.1002/ar.24188

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