Article
Human immunodeficiency virus type 1 envelope protein endocytosis mediated by a highly conserved intrinsic internalization signal in the cytoplasmic domain of gp41 is suppressed in the presence of the Pr55gag precursor protein.
Journal of virology - 1 Oct 1996
Egan M A, Carruth L M, Rowell J F, Yu X, Siliciano R F
Abstract excerpt
The mechanisms involved in the incorporation of viral glycoproteins into virions are incompletely understood. For retroviruses, incorporation may involve interactions between the Gag proteins of these viruses and the cytoplasmic domains of the relevant envelope (Env) glycoproteins. Recent studies...
Topics
- Amino Acid Sequence
- CD4-Positive T-Lymphocytes
- Cell Line
- Conserved Sequence
- Endocytosis
- Flow Cytometry
- Gene Products, gag
- HIV Envelope Protein gp41
- HIV-1
- Humans
- Mutation
- Protein Precursors
- Virus Assembly