Article
Genetic variation in immediate and delayed postictal refractory period in rats.
Brain research - 20 May 1996
Francis A, Fochtmann L
Abstract excerpt
We determined postictal refractoriness in Sprague-Dawley rats by comparing lengths of two suprathreshold ECS seizures given 15 s to 24 h apart. A bimodal (immediate and delayed) decrease in seizure duration was found, suggesting ECS alters mechanisms of seizure termination. Since adenosine is implicated in seizure termination, we determined immediate (30 s) and delayed (24 h) postictal ECS refractoriness in...
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