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Article

Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract.

Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 1996

Connell I, Agace W, Klemm P, Schembri M, Mărild S, Svanborg C

Abstract excerpt

Type 1 fimbriae are adhesion organelles expressed by many Gram-negative bacteria. They facilitate adherence to mucosal surfaces and inflammatory cells in vitro, but their contribution to virulence has not been defined. This study presents evidence that type 1 fimbriae increase the virulence of Escherichia coli for the urinary tract by promoting bacterial persistence and enhancing the inflammatory response to...

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Identifiers

PMID: 8790416
DOI: 10.1073/pnas.93.18.9827
PMCID: PMC38514

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