Article
Cryptococcal capsular polysaccharide utilizes an antigen-presenting cell to induce a T-suppressor cell to secrete TsF.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology - 1 Jan 2000
Blackstock R
Abstract excerpt
A T-T hybridoma (F6.6.2) which secretes a T-suppressor factor (TsF) specific for cryptococcal capsular polysaccharide (glucuronoxylomannan, GXM) was tested to determine if antigen-presenting cells (APC) were necessary for activation of the hybridoma to secrete TsF. Normal, syngeneic spleen cells were required along with GXM before TsF could be detected in culture supernatants. Ts cells did not secrete TsF unless...
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