Article
Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1.
Arthritis and rheumatism - 1 Jul 1994
Kavanaugh A F, Davis L S, Nichols L A, Norris S H, Rothlein R, Scharschmidt L A, Lipsky P E
Abstract excerpt
OBJECTIVE: To assess the safety and efficacy of a monoclonal antibody (MAb) to intercellular adhesion molecule 1 (ICAM-1; CD54) in rheumatoid arthritis (RA). METHODS: A phase I/II, open-label, dose-escalation study of 32 patients. RESULTS: During treatment, a peripheral CD3+/CD4+ lymphocytosis wa...
Topics
- Adult
- Antibodies, Monoclonal
- Antigens, CD
- Arthritis, Rheumatoid
- Cell Adhesion Molecules
- Cell Count
- Female
- Humans
- Hypersensitivity, Delayed
- Intercellular Adhesion Molecule-1
- Lymphocyte Subsets
- Lymphocytes
- Male
- Middle Aged
- Monocytes
- Neutrophils
- Phenotype