Article
Exclusion of linkage between idiopathic generalized epilepsies and the GABAA receptor alpha 1 and gamma 2 subunit gene cluster on chromosome 5.
Epilepsy research - 1 Apr 1996
Sander T, Hildmann T, Janz D, Wienker T F, Bianchi A, Bauer G, Sailer U, Scaramelli A, Neitzel H, Schmitz B, Bailey M E, Beck-Mannagetta G, Johnson K J, Darlison M G
Abstract excerpt
Hereditary factors play a major role in the etiology of idiopathic generalized epilepsies (IGEs). The pivotal function of ionotropic gamma-aminobutyric acid type A receptors (GABRs) in inhibitory neurotransmission in the mammalian central nervous system suggests that they may be involved in epile...
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