Article
Genetic probes of ribosomal RNA function.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 2000
O'Connor M, Brunelli C A, Firpo M A, Gregory S T, Lieberman K R, Lodmell J S, Moine H, Van Ryk D I, Dahlberg A E
Abstract excerpt
We have used a genetic approach to uncover the functional roles of rRNA in protein synthesis. Mutations were constructed in a cloned rrn operon by site-directed mutagenesis or isolated by genetic selections following random mutagenesis. We have identified mutations that affect each step in the process of translation. The data are consistent with the results of biochemical and phylogenetic analyses but, in...
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