Human interindividual variability in susceptibility to toxic effects: from annoying detail to a central determinant of risk.

doi:10.1016/0300-483x(96)03388-4

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Article

Human interindividual variability in susceptibility to toxic effects: from annoying detail to a central determinant of risk.

Toxicology - 17 Jul 1996

Hattis D

Abstract excerpt

It is unusual to find variability issues as the central focus of a scientific conference. The discussion below first suggests why variability has often been an "annoying detail" in both basic animal toxicology and the human testing of new drugs. Then it gives some reasons why improved quantitativ...

Topics

Animals
Carcinogens
Disease Susceptibility
Dose-Response Relationship, Drug
Environmental Pollutants
Genetic Variation
Humans
Risk Assessment
Toxicity Tests

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