Article
Molecular abnormality of a phosphoglycerate kinase variant (PGK-Alabama).
Blood cells, molecules & diseases - 1 Jan 1995
Yoshida A, Twele T W, Davé V, Beutler E
Abstract excerpt
The molecular abnormality of a phosphoglycerate kinase variant associated with severe red cell enzyme deficiency ( about 4% of normal) and episodes of hemolysis with jaundice was examined. The Michaelis constants for the substrates and co-enzymes (1.3-diphosphoglycerate, 3-phosphoglycerate, ATP and ADP) were not grossly different from that of normal. However that variant enzyme was very labile in vitro....
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