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Article

Trans effects in nitric oxide binding to myoglobin cavity mutant H93G.

Biochemistry - 16 Apr 1996

Decatur S M, Franzen S, DePillis G D, Dyer R B, Woodruff W H, Boxer S G

Abstract excerpt

When nitric oxide (NO) binds to heme proteins, it exerts a repulsive trans effect on the proximal ligand, resulting in weakening or rupture of the proximal ligand-iron bond. The general question of whether NO binding generates a five-coordinate complex with proximal ligand release is important for the function of enzymes such as guanylate cyclase. This question can be addressed by studying NO binding to the...

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PMID: 8664286
DOI: 10.1021/bi951661p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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