Effects of track structure and cell inactivation on the calculation of heavy ion mutation rates in mammalian cells.

Abstract excerpt

It has long been suggested that inactivation severely effects the probability of mutation by heavy ions in mammalian cells. Heavy ions have observed cross sections of inactivation that approach and sometimes exceed the geometric size of the cell nucleus in mammalian cells. In the track structure...

Topics

• Animals
• Cricetinae
• Cricetulus
• Humans
• Hypoxanthine Phosphoribosyltransferase
• Linear Energy Transfer
• Models, Biological
• Mutation