Article
Founding BRCA1 mutations in hereditary breast and ovarian cancer in southern Sweden.
American journal of human genetics - 1 Mar 1996
Johannsson O, Ostermeyer E A, Håkansson S, Friedman L S, Johansson U, Sellberg G, Brøndum-Nielsen K, Sele V, Olsson H, King M C, Borg A
Abstract excerpt
Nine different germ-line mutations in the BRCA1 breast and ovarian cancer susceptibility gene were identified in 15 of 47 kindreds from southern Sweden, by use of SSCP and heteroduplex analysis of all exons and flanking intron region and by a protein-truncation test for exon 11, followed by direc...
Topics
- Adult
- Aged
- Aged, 80 and over
- BRCA1 Protein
- Base Sequence
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Female
- Founder Effect
- Gene Frequency
- Genetic Linkage
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Humans