Article
A mutation in the lipoprotein lipase gene is the molecular basis of chylomicronemia in a colony of domestic cats.
The Journal of clinical investigation - 1 Mar 1996
Ginzinger D G, Lewis M E, Ma Y, Jones B R, Liu G, Jones S D
Abstract excerpt
Members of a domestic cat colony with chylomicronemia share many phenotypic features with human lipoprotein lipase (LPL) deficiency. Biochemical analysis reveals that these cats do have defective LPL catalytic activity and have a clinical phenotype very similar to human LPL deficiency. To determine the molecular basis underlying this biochemical phenotype, we have cloned the normal and affected cat LPL cDNAs and...
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