A mutation in the lipoprotein lipase gene is the molecular basis of chylomicronemia in a colony of domestic cats.

doi:10.1172/JCI118541

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Article

A mutation in the lipoprotein lipase gene is the molecular basis of chylomicronemia in a colony of domestic cats.

The Journal of clinical investigation - 1 Mar 1996

Ginzinger D G, Lewis M E, Ma Y, Jones B R, Liu G, Jones S D

Abstract excerpt

Members of a domestic cat colony with chylomicronemia share many phenotypic features with human lipoprotein lipase (LPL) deficiency. Biochemical analysis reveals that these cats do have defective LPL catalytic activity and have a clinical phenotype very similar to human LPL deficiency. To determi...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Cats
Chylomicrons
DNA, Complementary
Female
Humans
Lipoprotein Lipase
Male
Molecular Sequence Data
Mutation

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