Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential effects of two hydrocephalus/MASA syndrome-related mutations on the homophilic binding and neuritogenic activities of the cell adhesion molecule L1.

The Journal of biological chemistry - 22 Mar 1996

Zhao X, Siu C H

Abstract excerpt

The cell adhesion molecule L1 plays an important role in neural development. We have previously demonstrated that the second immunoglobulin-like domain (Ig2) of L1 contains both homophilic binding and neuritogenic activities (Zhao, X., and Siu, C.-H. (1995) J. Biol. Chem. 270, 29413-29421). Recently, two mutations (R184Q and H210Q) within the Ig2 region of the human L1 gene have been shown to be responsible for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Binding Sites
Share to Cricetinae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to DNA Primers

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 8636066
DOI: 10.1074/jbc.271.12.6563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential effects of two hydrocephalus/MASA syndrome-related mutations on the homophilic binding and neuritogenic activities of the cell adhesion molecule L1.PMID 8636066Read ↗

Identification of a homophilic binding site in immunoglobulin-like domain 2 of the cell adhesion molecule L1.Semantic proximity Read ↗

New domains of neural cell-adhesion molecule L1 implicated in X-linked hydrocephalus and MASA syndrome.Semantic proximity Read ↗

X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene.Semantic proximity Read ↗

X linked hydrocephalus and MASA syndrome.Semantic proximity Read ↗

L1-associated diseases: clinical geneticists divide, molecular geneticists unite.Semantic proximity Read ↗

Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A.Semantic proximity Read ↗

Gene analysis of L1 neural cell adhesion molecule in prenatal diagnosis of hydrocephalus.Semantic proximity Read ↗

Adhesion molecules and inherited diseases of the human nervous system.Semantic proximity Read ↗

L1CAM mutation in a Japanese family with X-linked hydrocephalus: a study for genetic counseling.Semantic proximity Read ↗

Genetic and clinical aspects of X-linked hydrocephalus (L1 disease): Mutations in the L1CAM gene.Semantic proximity Read ↗

Clinical and genetic features of L1 syndrome patients: Definition of two novel mutations.Semantic proximity Read ↗

The clinical spectrum of mutations in L1, a neuronal cell adhesion molecule.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.