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Article

The Malaysian experience in the typing of genetic variants of alpha-1-antitrypsin.

The Southeast Asian journal of tropical medicine and public health - 1 Jan 1995

Desa N M, Ismail Z, Beran Z, Musa S H

Abstract excerpt

It is known that alpha1-antitrypsin deficiency is associated with emphysema in adults and liver cirrhosis in neonates. The phenotypes PiZZ and PiSZ are considered to be high risk groups. alpha1-antitrypsin deficiency is one of the most common lethal congenital disorders in Europe and the USA, occurring in approximately 1 in 2,000 caucasians of North European descent. Studies in Malaysia have found that the...

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PMID: 8629132

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