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Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster.

Molecular and cellular biology - 1 May 1996

Dick T, Ray K, Salz H K, Chia W

Abstract excerpt

We report the molecular and genetic characterization of the cytoplasmic dynein light-chain gene, ddlc1, from Drosophila melanogaster. ddlc1 encodes the first cytoplasmic dynein light chain identified, and its genetic analysis represents the first in vivo characterization of cytoplasmic dynein function in higher eucaryotes. The ddlc1 gene maps to 4E1-2 and encodes an 89-amino-acid polypeptide with a high...

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Identifiers

PMID: 8628263
DOI: 10.1128/MCB.16.5.1966
PMCID: PMC231184

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