Article
Long-circulating bacteriophage as antibacterial agents.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 1996
Merril C R, Biswas B, Carlton R, Jensen N C, Creed G J, Zullo S, Adhya S
Abstract excerpt
The increased prevalence of multidrug-resistant bacterial pathogens motivated us to attempt to enhance the therapeutic efficacy of bacteriophages. The therapeutic application of phages as antibacterial agents was impeded by several factors: (i) the failure to recognize the relatively narrow host range of phages; (ii) the presence of toxins in crude phage lysates; and (iii) a lack of appreciation for the capacity...
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