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Article

Genetic conservation of Highlands J viruses.

Virology - 15 Apr 1996

Cilnis M J, Kang W, Weaver S C

Abstract excerpt

We studied molecular evolution of the mosquito-borne alphavirus Highlands J (HJ) virus by sequencing PCR products generated from 19 strains isolated between 1952 and 1994. Sequences of 1200 nucleotides including portions of the E1 gene and the 3' untranslated region revealed a relatively slow evolutionary rate estimated at 0.9-1.6 x 10(-4) substitutions per nucleotide per year. Phylogenetic trees indicated that...

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Identifiers

PMID: 8610461
DOI: 10.1006/viro.1996.0203

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