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Article

Unexpected beta2-microglobulin sequence diversity in individual rainbow trout.

Proceedings of the National Academy of Sciences of the United States of America - 2 Apr 1996

Shum B P, Azumi K, Zhang S, Kehrer S R, Raison R L, Detrich H W, Parham P

Abstract excerpt

For mammals beta2-microglobulin (beta2m), the light chain of major histocompatibility complex (MHC) class I molecules, is invariant (or highly conserved) and is encoded by a single gene unlinked to the MHC. We find that beta2m of a salmonid fish, the rainbow trout (Oncorhynchus mykiss), does not conform to the mammalian paradigm. Ten of 12 randomly selected beta2m cDNA clones from an individual fish have...

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Identifiers

PMID: 8610117
DOI: 10.1073/pnas.93.7.2779
PMCID: PMC39709

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