A cascade-mechanism of fat storing cell activation forms the basis of the fibrogenic reaction of the liver.

Article

A cascade-mechanism of fat storing cell activation forms the basis of the fibrogenic reaction of the liver.

Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 1995

Gressner A M, Chunfang G

Abstract excerpt

Evidence has been provided that fat storing cells (FSC) are the major source of extracellular matrix components (ECM), if these precursor cells are activated in areas of necroinflammation to proliferate and to switch from the retinoid storing to the ECM-producing phenotype termed myofibroblast (M...

Topics

Adipocytes
Animals
Cell Division
Cytokines
Endothelium
Extracellular Matrix
Humans
Inflammation
Kupffer Cells
Liver
Liver Cirrhosis
Models, Biological
Phenotype
Proteoglycans

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