Article
A cascade-mechanism of fat storing cell activation forms the basis of the fibrogenic reaction of the liver.
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 1995
Gressner A M, Chunfang G
Abstract excerpt
Evidence has been provided that fat storing cells (FSC) are the major source of extracellular matrix components (ECM), if these precursor cells are activated in areas of necroinflammation to proliferate and to switch from the retinoid storing to the ECM-producing phenotype termed myofibroblast (MFB). The mechanisms of FSC activation, which are crucial to fibrogenesis, have been studied under cell culture...
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