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Article

Increased instability of intermediate alleles in families with sporadic Huntington disease compared to similar sized intermediate alleles in the general population.

Human molecular genetics - 1 Oct 1995

Goldberg Y P, McMurray C T, Zeisler J, Almqvist E, Sillence D, Richards F, Gacy A M, Buchanan J, Telenius H, Hayden M R

Abstract excerpt

We have directly compared intergenerational stability of intermediate alleles (IAs) derived from new mutation families (IANM) for Huntington disease (HD) with IAs in the general population (IAGP) which occur in approximately 1 in 50 persons. Analysis of meiotic events in blood and sperm reveals that IANM are significantly more unstable than IAGP despite similar size. However, for both IANM and IAGP CAG changes...

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PMID: 8595415
DOI: 10.1093/hmg/4.10.1911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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