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Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux

1 Nov 1995

Abstract excerpt

Three copper-resistant variants of cultured Chinese hamster ovary (CHO) cells were isolated and each was shown to accumulate less intracellular copper than the parental cells when grown in copper-supplemented media. The reduced copper accumulation was related to enhanced copper efflux. As cultured cells from patients with Menkes disease (mutations in MNK; ATP7A gene) accumulate copper, probably due to defective...

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Identifiers

PMID: 8589689
DOI: 10.1093/hmg/4.11.2117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper effluxPMID 8589689Read ↗

The Menkes copper transporter is required for the activation of tyrosinase.Semantic proximity Read ↗

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network.Semantic proximity Read ↗

Characterization of the Menkes protein copper-binding domains and their role in copper-induced protein relocalization.Semantic proximity Read ↗

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells.Semantic proximity Read ↗

Identification of three novel mutations in the MNK gene in three unrelated Japanese patients with classical Menkes disease.Semantic proximity Read ↗

Studies on endocytic mechanisms of the Menkes copper-translocating P-type ATPase (ATP7A; MNK). Endocytosis of the Menkes protein.Semantic proximity Read ↗

Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease.Semantic proximity Read ↗

A conditional mutation affecting localization of the Menkes disease copper ATPase. Suppression by copper supplementation.Semantic proximity Read ↗

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase.Semantic proximity Read ↗

Intracellular localization and loss of copper responsiveness of Mnk, the murine homologue of the Menkes protein, in cells from blotchy (Mo blo) and brindled (Mo br) mouse mutants.Semantic proximity Read ↗

Abnormalities of copper accumulation in cell lines established from nine different alleles of mottled are the same as those found in Menkes disease.Semantic proximity Read ↗

The regulation of catalytic activity of the menkes copper-translocating P-type ATPase. Role of high affinity copper-binding sites.Semantic proximity Read ↗

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