[Characterization of tolerogen-producing cells and lymphoid tissues where self-tolerance is induced--a study on allogeneic bone marrow chimeras established with spontaneous leukemia prone mice].

Abstract excerpt

SL/Kh strain of mice provides a spontaneous pre-B cell leukemia model and AKR/J mice provides a spontaneous thymoma model. Using these leukemia-prone mice, protective influence of bone marrow (BM) transplantation and tolerance induction to a host antigen, Mls-1a, after BM reconstitution were studied. When SL/Kh mice were reconstituted with BM cells from allogeneic C57BL/6 mice, these [B6-->SL] chimeric mice...

Topics

• Animals
• Bone Marrow Transplantation
• Chimera
• Disease Models, Animal
• Graft vs Host Reaction
• Hyaluronan Receptors
• Immune Tolerance
• Immunosuppressive Agents
• Leukemia, B-Cell
• Mice