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Article

Evolutionary consequences of mutation and selection within an individual.

Genetics - 1 Nov 1995

Otto S P, Orive M E

Abstract excerpt

Whether in sexual or asexual organisms, selection among cell lineages during development is an effective way of eliminating deleterious mutations. Using a mathematical analysis, we find that relatively small differences in cell replication rates during development can translate into large differences in the proportion of mutant cells within the adult, especially when development involves a large number of cell...

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Identifiers

PMID: 8582622
DOI: 10.1093/genetics/141.3.1173
PMCID: PMC1206839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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