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Article

Two distinct temperature-sensitive alleles at the elav locus of Drosophila are suppressed nonsense mutations of the same tryptophan codon.

Genetics - 1 Nov 1995

Samson M L, Lisbin M J, White K

Abstract excerpt

The Drosophila gene elav encodes a 483-amino-acid-long nuclear RNA binding protein required for normal neuronal differentiation and maintenance. We molecularly analyzed the three known viable alleles of the gene, namely elavts1, elavFliJ1, and elavFliJ2, which manifest temperature-sensitive phenotypes. The modification of the elavFliJ1 allele corresponds to the change of glycine426 (GGA) into a glutamic acid...

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Identifiers

PMID: 8582616
DOI: 10.1093/genetics/141.3.1101
PMCID: PMC1206833

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Two distinct temperature-sensitive alleles at the elav locus of Drosophila are suppressed nonsense mutations of the same tryptophan codon.PMID 8582616Read ↗

Evidence for 3' untranslated region-dependent autoregulation of the Drosophila gene encoding the neuronal nuclear RNA-binding protein ELAV.Semantic proximity Read ↗

Overlapping Activities of ELAV/Hu Family RNA Binding Proteins Specify the Extended Neuronal 3' UTR Landscape in Drosophila.Semantic proximity Read ↗

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ELAV mediates 3' UTR extension in the Drosophila nervous system.Semantic proximity Read ↗

Function of RRM domains of Drosophila melanogaster ELAV: Rnp1 mutations and rrm domain replacements with ELAV family proteins and SXL.Semantic proximity Read ↗

WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland.Semantic proximity Read ↗

found in neurons, a third member of the Drosophila elav gene family, encodes a neuronal protein and interacts with elav.Semantic proximity Read ↗

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Gene elav of Drosophila melanogaster: a prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans.Semantic proximity Read ↗

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