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Article

Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts.

Development (Cambridge, England) - 1 Nov 1995

Kapur R P, Sweetser D A, Doggett B, Siebert J R, Palmiter R D

Abstract excerpt

Mice homozygous for the piebald lethal (sl) mutation, which have a complete deletion of endothelin receptor-B, fail to form ganglion cells in the distal large intestine and are nearly devoid of cutaneous melanocytes. These phenotypic features stem from incomplete colonization of the hindgut and skin by neural crest-derived neuroblasts and melanoblasts, respectively. We have used expression of a transgene,...

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Identifiers

PMID: 8582288
DOI: 10.1242/dev.121.11.3787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts.PMID 8582288Read ↗

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L1cam acts as a modifier gene for members of the endothelin signalling pathway during enteric nervous system developmentSemantic proximity Read ↗

Impaired growth and differentiation of diploid but not immortal melanoblasts from endothelin receptor B mutant (piebald) mice.Semantic proximity Read ↗

Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.Semantic proximity Read ↗

Hirschsprung's disease: genetic mutations in mice and men.Semantic proximity Read ↗

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 geneSemantic proximity Read ↗

Temporally Distinct Requirements for Endothelin Receptor B in the Generation and Migration of Gut Neural Crest Stem CellsSemantic proximity Read ↗

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons.Semantic proximity Read ↗

Suppression of the melanogenic potential of migrating neural crest-derived cells by the branchial arches.Semantic proximity Read ↗

Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes.Semantic proximity Read ↗

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