Article
Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts.
Development (Cambridge, England) - 1 Nov 1995
Kapur R P, Sweetser D A, Doggett B, Siebert J R, Palmiter R D
Abstract excerpt
Mice homozygous for the piebald lethal (sl) mutation, which have a complete deletion of endothelin receptor-B, fail to form ganglion cells in the distal large intestine and are nearly devoid of cutaneous melanocytes. These phenotypic features stem from incomplete colonization of the hindgut and s...
Topics
- Animals
- Enteric Nervous System
- Gene Deletion
- Genotype
- Melanocytes
- Mice
- Mice, Transgenic
- Models, Biological
- Neurons
- Phenotype
- Polymerase Chain Reaction
- Receptors, Endothelin
- Signal Transduction