Article
Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 1994
Pavan W J, Tilghman S M
Abstract excerpt
Mice homozygous for the piebald lethal (sl) mutation have a predominantly white coat due to the absence of neural crest-derived melanocytes in the hair follicles. To investigate the time in embryonic development when the s1 gene affects the melanocyte lineage, we compared the distribution of mela...
Topics
- Animals
- Cell Division
- Embryo, Mammalian
- Genes, Lethal
- Head
- Immunohistochemistry
- Intramolecular Oxidoreductases
- Isomerases
- Melanocytes
- Mice
- Mice, Inbred C57BL
- Mutation
- Neural Crest
- Piebaldism
- Polymerase Chain Reaction