Article
A gene involved in XY sex reversal is located on chromosome 9, distal to marker D9S1779.
American journal of human genetics - 1 Sept 1998
Flejter W L, Fergestad J, Gorski J, Varvill T, Chandrasekharappa S
Abstract excerpt
The genetic mechanisms involved in sex differentiation are poorly understood, and progress in identification of the genes involved has been slow. The fortuitous finding of chromosomal rearrangements in association with a sex-reversed phenotype has led to the isolation of SRY and SOX9, both shown...
Topics
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- DNA-Binding Proteins
- Disorders of Sex Development
- Female
- Genetic Markers
- High Mobility Group Proteins
- Humans
- Infant, Newborn
- Karyotyping
- Male
- Microsatellite Repeats
- Multigene Family
- Nuclear Proteins
- Pedigree
- Phenotype
- Polymerase Chain Reaction