Rapid diagnosis of beta-thalassaemia by mutagenically separated polymerase chain reaction (MS-PCR) and its application to prenatal diagnosis.

doi:10.1111/j.1365-2141.1995.tb05354.x

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Article

Rapid diagnosis of beta-thalassaemia by mutagenically separated polymerase chain reaction (MS-PCR) and its application to prenatal diagnosis.

British journal of haematology - 1 Nov 1995

Chang J G, Lu J M, Huang J M, Chen J T, Liu H J, Chang C P

Abstract excerpt

We have developed a rapid and simple PCR-based method which is modified from the mutagenically separated polymerase chain reaction (MS-PCR) to detect the molecular defects of beta-thalassaemia. We can use this technique to amplify normal and mutant alleles of the beta-globin gene in the same reac...

Topics

Base Sequence
Female
Hemoglobin E
Homozygote
Humans
Male
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Prenatal Diagnosis
beta-Thalassemia

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