[Familial bladder cancer].

Abstract excerpt

Despite little evidence for a hereditary cause of most cases of bladder cancer, two different patterns of genetic involvement have been suggested: an autosomal dominant pattern that accounts for a very small number of cases and a multifactorial, polygenic pattern involving genetic and environmental interaction. Inherited homozygous defect of the glutathione S-transferase M1 gene is a good example of the latter...

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