Article
[Familial occurrence of thyroid tumors].
Nihon rinsho. Japanese journal of clinical medicine - 1 Nov 1995
Kameyama K, Takami H, Hosoda Y
Abstract excerpt
In 1986, familial medullary thyroid carcinoma (FMTC) was recognized clinically as a distinct entity, clearly distinguished from multiple endocrine neoplasia (MEN), being characterized by the development of MTC in the absence of any additional neoplasms. Ret proto-oncogene was first identified in 1985 using transformation assay. The gene was mapped to the chromosome 10, similar to MEN and FMTC, and was expressed...
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