Article
Linkage of preaxial polydactyly type 2 to 7q36.
American journal of medical genetics - 28 Aug 1995
Hing A V, Helms C, Slaugh R, Burgess A, Wang J C, Herman T, Dowton S B, Donis-Keller H
Abstract excerpt
We have characterized a 6-generation North American Caucasian kindred segregating one form of preaxial polydactyly type 2 (PPD-2). We demonstrate linkage to the 7q36 region and describe a submicroscopic telomeric chromosomal deletion in phase with the PPD-2 phenotype. Recently, several kindreds s...
Topics
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 7
- Genetic Linkage
- Haplotypes
- Heterozygote
- Humans
- Hybrid Cells
- Molecular Sequence Data
- Mutation
- Pedigree
- Polydactyly
- Polymorphism, Genetic
- Thumb
- Toes