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Article

Identity-by-descent refines mapping of candidate regions for preaxial polydactyly II /III in a large Chinese pedigree.

Hereditas - 1 Jan 2018

Yang Xingyan, Shen Quankuan, Sulaiman Xierzhatijiang, Liu Hequn, Peng Minsheng, Zhang Yaping

Abstract excerpt

Preaxial polydactyly (PPD) is congenital hand malformation characterized by the duplication of digit. Herein, we scan the genome-wide SNPs for a large Chinese family with PPD-II/III. We employ the refined IBD algorithm to identify the identity-by-decent (IBD) segments and compare the frequency among the patients and normal relatives. A total of 72 markers of 0.01 percentile of the permutation are identified as...

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Source

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Identifiers

PMID: 28690477
DOI: 10.1186/s41065-017-0040-6
PMCID: PMC5496229

Genes

LMBR1
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identity-by-descent refines mapping of candidate regions for preaxial polydactyly II /III in a large Chinese pedigree.PMID 28690477Read ↗

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