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Article

Evidence for developmentally programmed transdifferentiation in mouse esophageal muscle.

Science (New York, N.Y.) - 15 Dec 1995

Patapoutian A, Wold B J, Wagner R A

Abstract excerpt

Transdifferentiation is a relatively rare phenomenon in which cells of one differentiated type and function switch to a second discrete identity. In vertebrate embryos, smooth muscle and skeletal muscle are distinct tissues that arise from separate compartments of the mesoderm. The musculature of the mouse esophagus was found to undergo a conversion from smooth muscle in the fetus to skeletal muscle during early...

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Identifiers

PMID: 8525375
DOI: 10.1126/science.270.5243.1818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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