Article
Detection of the Ki‐67 antigen in fixed and wax‐embedded sections with the monoclonal antibody MIB1
1 Apr 1993
Abstract excerpt
Novel antibodies have been generated by immunizing with bacterially expressed fragments of the repetitive motif of the Ki-67 gene. One such antibody, MIB1, recognizes a fixation and embedding resistant epitope on the Ki-67 protein if sections are previously microwaved in a citrate buffer. We have investigated the utility of this antibody as a marker of cell proliferation in archival material. The microwave...
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