Article
Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus.
Genetics - 1 May 1993
Dorer D R, Cadden M A, Gordesky-Gold B, Harries G, Christensen A C
Abstract excerpt
One of the most extreme examples of gene dosage sensitivity is the Triplo-lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the...
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